Publications

1 Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans,
Schiffer TA, Larsen FJ, Lundberg JO, Weitzberg E, Lindholm P. Respir Physiol Neurobiol. 2012 Oct 23. doi:pii: S1569-9048(12)00271-6. 10.1016/j.resp.2012.09.008. [Epub ahead of print] PubMed PMID: 23099220.

2 Regulation of mitochondrial function and energetics by reactive nitrogen oxides,
Larsen FJ, Schiffer TA, Weitzberg E, Lundberg JO. Free Radic Biol Med. 2012 Aug 31;53(10):1919-1928. doi: 10.1016/j.freeradbiomed.2012.08.580. [Epub ahead of print] PubMed PMID: 22989554.

3 Biology of nitrogen oxides in the gastrointestinal tract,
Lundberg JO, Weitzberg E. Gut. 2012 Jan 20. [Epub ahead of print] PubMed PMID: 22267589.

4 Decreased leukocyte recruitment by inorganic nitrate and nitrite in microvascular inflammation and NSAID-induced intestinal injury.
Jädert C, Petersson J, Massena S, Ahl D, Grapensparr L, Holm L, Lundberg JO, Phillipson M. Free Radic Biol Med. 2012 Feb 1;52(3):683-92. Epub 2011 Nov 30. PubMed PMID: 22178413.

Redox and Inflammation signaling meeting (Wim Vanden Berghe)
Phytochemicals and diet in lifestyle disease: epigenetic friends or foe. Luxemburg 2012, RedCat Meeting on Redox Catalysis from Chemistry to Biology

Second Clinical Epigenetics International Meeting (Wim Vanden Beghe)
Phytochemicals and diet in lifestyle disease: epigenetic friends or foe. Homburg/Saar, Germany, 9/03/2012 10/03/2012,

13th congres Nutrition & Phytotherapie (Wim Vanden Berghe)
Nutrition & phytochemicals: epigenetic remedies against chronic inflammatory disorders. Chateau du Lac de Genval, 24 march 2012, Brussels

Cost Meeting Riga, Epigenetics: Bench to Bedside (Wim Vanden Berghe)
Epigenomic profiling of phytochemical effects in lifestyle disease: challenges & Pitfalls, 26-27 april 2012, Riga

Third International Congress on Pharmacology of Natural Products (Wim Vanden Berghe)
Nature or nurture: let’s food be your epigenetic medicine, Faprunatura. 6-9 june 2012, Topes de Collantes, Sancti Spiritus, Cuba

Cost Meeting, Personalised Medicine: Better Healthcare for the Future - A Rational Approach Focusing on Bioinformatics, Medicinal Chemistry and Medicine (Wim Vanden Berghe)
Epigenomic profiling of phytochemical effects in lifestyle disease: challenges & pitfalls. 17 - 22 June 2012, Larnaca, Cyprus, COST meeting (with EU parliament members). video.

Nutriphyt (celebration 10 year nutrition company) (Wim Vanden Berghe)
Nature or nurture: let food be your epigenetic medicine. Roeselare, Belgium, 29 september 2012, link

Meeting Molecular Medicine Conference 2012 “Alternative Strategies Against Cancer And Inflammation” (Wim Vanden Berghe)
Nature or nurture: let food be your epigenetic medicine, Chairman session epigenetics. Bangkok, 19-22 december 2012, Belgium

1 Dietary inorganic nitrate improves mitochondrial efficiency in humans,
Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E. Cell Metab. 2011 Feb 2;13(2):149-59, link.

2 Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension,
Carlström M, Persson AE, Larsson E, Hezel M, Scheffer PG, Teerlink T, Weitzberg E, Lundberg JO. Cardiovasc Res. 2011 Feb 15;89(3):574-85, link

3 Roles of dietary inorganic nitrate in cardiovascular health and disease,
Lundberg JO, Carlström M, Larsen FJ, Weitzberg E. Cardiovasc Res. 2011 Feb 15;89(3):525-32, link

5th international conference on oxidative stress in skin medicine and biology (Win Vanden Berghe)
Nutritional phytochemicals as epigenetic modulators in cancer-inflammation, Andros, 31/08/2011 5/09/2011, Greece

5th International Conference on Polyphenols and Health (Wim Vanden Berghe)
Phytochemicals and diet in cancer: epigenetic friends or foe, Sitges-Barcelona, Spain, 17/10/2011 21/10/2011

Mainau Discoveries Exhibition
This year, the FLAVIOLA project is featured in the Discoveries Health Exhibition hosted on the island of Mainau – Germany’s most famous botanical garden. The exhibition is organised by the Lindau Nobel Laureate Meetings and forms part of the Year of Science 2011 (“Research for Our Health”), a Federal Ministry of Education and Research (BMBF) initiative. The FLAVIOLA project is showcased in the pavilion of Mars, Incorporated – one of the consortium partners – and the exhibition is designed to enable visitors of all ages to explore a range of important scientific issues. It is expected that Mainau will receive about 500,000 visitors during the exhibition period (May 20 – September 4, 2011).

Flyers
The project has produced two brochures to raise awareness of FLAVIOLA among the scientific community, the patients, and the interested public.
One brochure gives a detailed description of the project objectives and includes a FAQs section. This flyer was conceived to address scientific community mainly (Download the flyer)
To target a broader audience, a second flyer was created. This second flyer gives very brief information about FLAVIOLA and redirects the reader to the FLAVIOLA website for further information (Download the teaser flyer)

1 The Biological Relevance of Direct Antioxidant Effects of Polyphenols for Cardiovascular Health in Humans Is Not Established,
Peter C. H. Hollman, Aedin Cassidy, Blandine Comte, Marina Heinonen, Myriam Richelle, Elke Richling, Mauro Serafini, Augustin Scalbert, Helmut Sies, and Stephane Vidry, The Journal of Nutrition 2011, link

2 The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo,
Ottaviani JI, Momma TY, Heiss C, Kwik-Uribe C, Schroeter H, Keen CL 2011,Free Radic Biol Med 50:237-244, link

3 Abstract: Dietary inorganic nitrate mobilizes circulating angiogenic cells and reverses endothelial dysfunction. DGK. Mannheim,
Heiss C, Meyer C, Heinen Y, Totzeck M, Luedike P, Ayoub N, Kehmeier E, Lundberg JO, Weitzberg E, Kelm M, Hendgen-Cotta U, Rassaf T 2011Clin Res Cardiol 100, Suppl 1, April 2011 P1735

4 Abstract: Dietary nitrate mobilizes circulating angiogenic cells and exerts cytoprotective angiogenic effect in the ischemic hindlimb model of mice,
Kropp M, Hendgen-Cotta U, Schicho A, Lüdike P, Totzeck M, Stock P, Heiss C, Niessen M, Kelm M, Rassaf T, Clin Res Cardiol 100, Suppl 1 April 2011 1. P670

5 Abstract: Dietary inorganic nitrate mobilizes circulating angiogenic cells and reverses endothelial dysfunction,
Heiss C, Meyer C, Heinen Y, Totzeck M, Lüdike P, Ayoub N, Kehmeier E, Lundberg JO, Weitzberg E, Kelm M, Hendgen-Cotta U, Rassaf T , Conference :Approaching the Clinic: Nitrite and Nitrate Pathophysiology and Therapy May 11-13, 2011 in Atlanta, Georgia

1 The biological role of nitrate and nitrite: the times they are a-changin',
Lundberg JO, Weitzberg E. Nitric Oxide. 2010 Feb 15;22(2):61-3. link

2 Nitrated oleic acid up-regulates PPARgamma and attenuates experimental inflammatory bowel disease,
Borniquel S, Jansson EA, Cole MP, Freeman BA, Lundberg JO. Free Radic Biol Med. 2010 Feb 15;48(4):499-505, link

3 Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise,
Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Radic Biol Med. 2010 Jan 15;48(2):342-7, link

4 Arginase inhibition mediates cardioprotection during ischaemia reperfusion,
Jung C, Gonon AT, Sjöquist PO, Lundberg JO, Pernow J. Cardiovasc Res. 2010 Jan 1;85(1):147-54, link

5 Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care,
Weitzberg E, Hezel M, Lundberg JO. Anesthesiology. 2010 Dec;113(6) 1460-75, link

7 Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice,
Carlström M, Larsen FJ, Nyström T, Hezel M, Borniquel S, Weitzberg E, Lundberg JO. Proc Natl Acad Sci U S A. 2010 Oct 12, link

8 NO-synthase independent NO generation in mammals,
Lundberg JO, Weitzberg E. Biochem Biophys Res Commun. 2010 May 21;396(1):39-45, link

9 Is sunlight good for our heart?
Feelisch M, Kolb-Bachofen V, Liu D, Lundberg JO, Revelo LP, Suschek CV,Weller RB. Eur Heart J. 2010 May;31(9):1041-5, link

10 Enhanced xanthine oxidoreductase expression and tissue nitrate reduction in germ free mice,
Huang L, Borniquel S, Lundberg JO. Nitric Oxide. 2010 Feb 15;22(2):191-5, link

11 Chocolate consumption, blood pressure, and cardiovascular risk,
Heiss C, Kelm M 1. Eur Heart J 2010 31:1554-1556, link

12 Flavanols and cardiovascular disease prevention,
Heiss C, Keen CL, Kelm M 2010, Eur Heart J. 31(21):2583-2592, link

13 Nitrate-nitrite-nitric oxide pathway, implications for anesthesiology and intensive care,
Weitzberg E, Hezel M, Lundberg JO. Anesthesiology. 2010
Dec;113(6):1460-75. Review. PubMed PMID: 21045638.


14 Enhanced xanthine oxidoreductase expression and tissue nitrate reduction in germ free mice,
Huang L, Borniquel S, Lundberg JO. Nitric Oxide. 2010 Feb 15;22(2):191-5. PubMed PMID: 20142047.

NUTRIM symposium in Maastricht
Flaviola: Effects of Cocoa Flavanols on Cardiovascular Health, Erik J.B. Ruijters, Guido R.M.M. Haenen, Antje R. Weseler, Aalt Bast, Poster

1 Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease,
Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile A, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y, 2010 J Am Coll Cardiol. 56:218-224, link

2 The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo,
Ottaviani JI, Momma TY, Heiss C, Kwik-Uribe C, Schroeter H, Keen CL 2011,Free Radic Biol Med 50:237-244, link

3 Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs,
Schroeter H, Heiss C, Spencer JPE, Keen CL, Lupton JR, Schmitz HH (2010) Mol Aspects Med. 31:546-557, link

1 Nitrate and nitrite in biology, nutrition and therapeutics
Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, CabralesP, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M,Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurryK, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A,Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E, Nat Chem Biol. 2009 Dec; 5(12):865-9, link

2 The biological role of nitrate and nitrite: the times they are a-changin,
Lundberg JO, Weitzberg E. Nitric Oxide. 2010 Feb 15;22(2):61-3. Epub 2009 Nov 15. PubMed PMID: 19919855.

3rd bi-annual Symposium on DNA methylation and cancer (Wim Vanden Berghe)
"Let food be your epigenetic medicine", symposium on Translational Cancer Epigenetics, October 09 2009, University Hospital of the RWTH Aachen

Düsseldorf, Germany, FLAVIOLA kick-off meeting
A public presentation of the project has been given during the first day of the kick-off meeting held in Düsseldorf, Germany (14/09/2009). It is a general introduction of the project available as a separate pdf file and can be downloaded from the public area of the FLAVIOLA web-site (link to the presentation)

Press release
UDUS prepared a press release, which appeared on the homepage of UDUS on the 10th of September 2010 and in the Neue Ruhr Zeitung / Neue Rhein Zeitung (local newspaper) on September 13th 2010 (Link to the Journal)

1 Abstract: Identification of a major mediator through which cocoa flavanols enhance vascular function. DGK 2009
Heiss C, Momma TY, Sievers RE, Chen Q, Keen CL, Yeghiazarians Y, Schroeter H, Springer ML (2009) Mannheim. Clin Res Cardiol 98- Suppl.

2 Abstract: Flavanol-rich Cocoa Mobilizes Endothelial Progenitor Cells Predicting the Reversal of Endothelial Dysfunction in Optimally Medicated CAD Patients,
Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile A, Rassaf T, Mihardja S, Devereaux M, Springer ML, Boyle A, Grossman W, Schroeter H, Yeghiazarians Y (2009)Clin Res Cardiol 98- Suppl 1,

3 Abstract: Flavanol-rich Cocoa Mobilizes Endothelial Progenitor Cells Predicting the Reversal of Endothelial Dysfunction in Optimally Medicated CAD Patients,
Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile A, Rassaf T, Mihardja S, Devereaux M, Springer ML, Boyle A, Grossman W, Schroeter H, Yeghiazarians Y (2009), Oral presentations

4 Stereochemical Properties of Flavanols Influence Vasodilatory Activity in vivo,
Momma TY, Ottaviani JI, Springer ML, Schroeter H, Keen CL, Heiss C (2009) ICPH 2009, Harrogate, UK.