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FLAVIOLA Publications

This page reports FLAVIOLA dissemination activities (peer reviewed articles, presentations at conferences & workshops, popular scientific articles, press releases, flyers, etc) as well as relevant other publications related to the FLAVIOLA project.

2015

Peer reviewed articles - 2015

1 Central role of eNOS in the maintenance of endothelial homeostasis.
Heiss C, Rodriguez-Mateos A, Kelm M., Antioxidants & redox signaling. 2015; 22(14):1230-42.

2 Measurement of endothelium-dependent vasodilation in mice--brief report.
Schuler D, Sansone R, Freudenberger T, Rodriguez-Mateos A, Weber G, et al., Arteriosclerosis, thrombosis, and vascular biology. 2014; 34(12):2651-7.
3 Influence of age on the absorption, metabolism, and excretion of cocoa flavanols in healthy subjects.
Rodriguez-Mateos A, Cifuentes-Gomez T, Gonzalez-Salvador I, Ottaviani JI, Schroeter H, et al., Molecular nutrition & food research. 2015;

4 Uptake and metabolism of (-)-epicatechin in endothelial cells.
Rodriguez-Mateos A, Toro-Funes N, Cifuentes-Gomez T, Cortese-Krott M, Heiss C, et al. Archives of biochemistry and biophysics. 2014; 559:17-23., PubMed [journal] PMID: 24717599

5 Interactions between cocoa flavanols and inorganic nitrate: additive effects on endothelial function at achievable dietary amounts.
Rodriguez-Mateos A, Hezel M, Aydin H, Kelm M, Lundberg JO, et al., Free radical biology & medicine. 2015; 80:121-8.

6 Associations between flavan-3-ol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk). link
Vogiatzoglou A, Mulligan AA, Bhaniani A, Lentjes MA, McTaggart A, Luben RN, Heiss C, Kelm M, Merx MW, Spencer JP, Schroeter H, Khaw KT, Kuhnle GG., Free Radic Biol Med. 2015 Jul;84:1-10.

7 Flavonoid intake in European adults (18 to 64 years).
Vogiatzoglou A, Mulligan AA, Lentjes MA, Luben RN, Spencer JP, Schroeter H, Khaw KT, Kuhnle GG, PLoSOne. 2015 May 26;10(5):e0128132. doi: 10.1371/journal.pone.0128132. eCollection 2015. link

8 Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial.
Heiss C, Sansone R, Karimi H, Krabbe M, Schuler D, Rodriguez-Mateos A, Kraemer T, Cortese-Krott MM, Kuhnle GG, Spencer JP, Schroeter H, Merx MW, Kelm M; FLAVIOLA Consortium, European Union 7th Framework Program.
Age (Dordr). 2015 Jun;37(3):9794

9 Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomized, controlled, double-masked trial.
Sansone R, Rodriguez-Mateos A, Heuel J, Falk D, Schuler D, Wagstaff R, Kuhnle G, Spencer J, Schroeter H, Merx M, Kelm, Heiss C., Brit J Nutr 2015

10 Factors Affecting the Absorption, Metabolism and Excretion of Cocoa Flavanols in Humans.
Cifuentes-Gomez T, Rodriguez-Mateos A, Gonzalez-Salvador I, Alanon M and Spencer JPE. J Agric Food Chem 2015.

2014

Peer reviewed articles - 2014

1 Assessment of the dietary intake of total flavan-3-ols, monomeric flavan-3-ols, proanthocyanidins and theaflavins in the European Union.
Vogiatzoglou A, Mulligan AA, Luben RN, Lentjes MA, Heiss C, Kelm M, Merx MW, Spencer JP, Schroeter H, Kuhnle GG. Br J Nutr. 2014 Apr 28;111(8):1463-73. doi:10.1017/S0007114513003930.

2 Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients.
Horn P, Amabile N, Angeli FS, Sansone R, Stegemann B, et al., The British journal of nutrition. 2014; 111(7):1245-52.

3 Berry (poly)phenols and cardiovascular health.
Rodriguez-Mateos A1, Heiss C, Borges G, Crozier A., J Agric Food Chem. 2014 May 7;62(18):3842-51. doi: 10.1021/jf403757g.

4 Estimated dietary intakes and sources of flavanols in the German population (German National Nutrition Survey II).
Vogiatzoglou A, Heuer T, Mulligan AA, Lentjes MA, Luben RN, Kuhnle GG, Eur J Nutr. 2014;53(2):635-43. doi:10.1007/s00394-013-0572-0

5 Flavanol metabolites reduce monocyte adhesion on an endothelial monolayer and module expression of genes and protein at physiologically relevant concentration.
Claude, Sylvain; Boby, Celine; Rodriguez-Mateos, Ana; Spencer, Jeremy; GeĢrard, Nicolas; Morand, Christine; Milenkovic, Dragan; Human nutrition. Mol Nutr Food Res. 2014 May;58(5):1016-27. doi: 10.1002/mnfr.201300658. Epub 2014 Jan 15.

2013

Peer reviewed articles - 2013
Popular scientific articles - press releases- flyers - 2013

1 Understanding the health benefits of flavanols
European Commission's "Research*eu results magazine"
, October 2013 link

2012

Peer reviewed articles - 2012

1 Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans.
Ottaviani JI, Kwik-Uribe C, Keen CL, Schroeter H., Am J Clin Nutr. 2012 Apr;95(4):851-8. doi: 10.3945/ajcn.111.028340. Epub 2012 Feb 29.

2 Effects of sugar type on the absorption and metabolism of flavanols.
Rodriguez-Mateos A, Oruna-Concha J, Kwik-Uribe C, Vidal A, Spencer JPE. Brit J Nutr 2012, 108(12):2243-50.
Presentations at conferences and workshops - 2012

Redox and Inflammation signaling meeting (Wim Vanden Berghe)
Phytochemicals and diet in lifestyle disease: epigenetic friends or foe. Luxemburg 2012, RedCat Meeting on Redox Catalysis from Chemistry to Biology

Second Clinical Epigenetics International Meeting (Wim Vanden Beghe)
Phytochemicals and diet in lifestyle disease: epigenetic friends or foe. Homburg/Saar, Germany, 9/03/2012 10/03/2012,

13th congres Nutrition & Phytotherapie (Wim Vanden Berghe)
Nutrition & phytochemicals: epigenetic remedies against chronic inflammatory disorders. Chateau du Lac de Genval, 24 march 2012, Brussels

Cost Meeting Riga, Epigenetics: Bench to Bedside (Wim Vanden Berghe)
Epigenomic profiling of phytochemical effects in lifestyle disease: challenges & Pitfalls, 26-27 april 2012, Riga

Third International Congress on Pharmacology of Natural Products (Wim Vanden Berghe)
Nature or nurture: let’s food be your epigenetic medicine, Faprunatura. 6-9 june 2012, Topes de Collantes, Sancti Spiritus, Cuba

Cost Meeting, Personalised Medicine: Better Healthcare for the Future - A Rational Approach Focusing on Bioinformatics, Medicinal Chemistry and Medicine (Wim Vanden Berghe)
Epigenomic profiling of phytochemical effects in lifestyle disease: challenges & pitfalls. 17 - 22 June 2012, Larnaca, Cyprus, COST meeting (with EU parliament members). video.

Nutriphyt (celebration 10 year nutrition company) (Wim Vanden Berghe)
Nature or nurture: let food be your epigenetic medicine. Roeselare, Belgium, 29 september 2012, link

Meeting Molecular Medicine Conference 2012 “Alternative Strategies Against Cancer And Inflammation” (Wim Vanden Berghe)
Nature or nurture: let food be your epigenetic medicine, Chairman session epigenetics. Bangkok, 19-22 december 2012, Belgium

2011

Peer reviewed articles - 2011

1 Dietary inorganic nitrate improves mitochondrial efficiency in humans,
Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E. Cell Metab. 2011 Feb 2;13(2):149-59, link.

2 Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension,
Carlström M, Persson AE, Larsson E, Hezel M, Scheffer PG, Teerlink T, Weitzberg E, Lundberg JO. Cardiovasc Res. 2011 Feb 15;89(3):574-85, link

3 Roles of dietary inorganic nitrate in cardiovascular health and disease,
Lundberg JO, Carlström M, Larsen FJ, Weitzberg E. Cardiovasc Res. 2011 Feb 15;89(3):525-32, link
Presentations at conferences and workshops - 2011

5th international conference on oxidative stress in skin medicine and biology (Win Vanden Berghe)
Nutritional phytochemicals as epigenetic modulators in cancer-inflammation, Andros, 31/08/2011 5/09/2011, Greece

5th International Conference on Polyphenols and Health (Wim Vanden Berghe)
Phytochemicals and diet in cancer: epigenetic friends or foe, Sitges-Barcelona, Spain, 17/10/2011 21/10/2011

Mainau Discoveries Exhibition

This year, the FLAVIOLA project is featured in the Discoveries Health Exhibition hosted on the island of Mainau – Germany’s most famous botanical garden. The exhibition is organised by the Lindau Nobel Laureate Meetings and forms part of the Year of Science 2011 (“Research for Our Health”), a Federal Ministry of Education and Research (BMBF) initiative. The FLAVIOLA project is showcased in the pavilion of Mars, Incorporated – one of the consortium partners – and the exhibition is designed to enable visitors of all ages to explore a range of important scientific issues. It is expected that Mainau will receive about 500,000 visitors during the exhibition period (May 20 – September 4, 2011).
Popular scientific articles - press releases- flyers - 2011

Flyers
The project has produced two brochures to raise awareness of FLAVIOLA among the scientific community, the patients, and the interested public.
One brochure gives a detailed description of the project objectives and includes a FAQs section. This flyer was conceived to address scientific community mainly (Download the flyer)
To target a broader audience, a second flyer was created. This second flyer gives very brief information about FLAVIOLA and redirects the reader to the FLAVIOLA website for further information (Download the teaser flyer)
FLAVIOLA Related publications - 2011

1 The Biological Relevance of Direct Antioxidant Effects of Polyphenols for Cardiovascular Health in Humans Is Not Established,
Peter C. H. Hollman, Aedin Cassidy, Blandine Comte, Marina Heinonen, Myriam Richelle, Elke Richling, Mauro Serafini, Augustin Scalbert, Helmut Sies, and Stephane Vidry, The Journal of Nutrition 2011, link

2 The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo,
Ottaviani JI, Momma TY, Heiss C, Kwik-Uribe C, Schroeter H, Keen CL 2011,Free Radic Biol Med 50:237-244, link

3 Abstract: Dietary inorganic nitrate mobilizes circulating angiogenic cells and reverses endothelial dysfunction. DGK. Mannheim,
Heiss C, Meyer C, Heinen Y, Totzeck M, Luedike P, Ayoub N, Kehmeier E, Lundberg JO, Weitzberg E, Kelm M, Hendgen-Cotta U, Rassaf T 2011Clin Res Cardiol 100, Suppl 1, April 2011 P1735

4 Abstract: Dietary nitrate mobilizes circulating angiogenic cells and exerts cytoprotective angiogenic effect in the ischemic hindlimb model of mice,
Kropp M, Hendgen-Cotta U, Schicho A, Lüdike P, Totzeck M, Stock P, Heiss C, Niessen M, Kelm M, Rassaf T, Clin Res Cardiol 100, Suppl 1 April 2011 1. P670

5 Abstract: Dietary inorganic nitrate mobilizes circulating angiogenic cells and reverses endothelial dysfunction,
Heiss C, Meyer C, Heinen Y, Totzeck M, Lüdike P, Ayoub N, Kehmeier E, Lundberg JO, Weitzberg E, Kelm M, Hendgen-Cotta U, Rassaf T , Conference :Approaching the Clinic: Nitrite and Nitrate Pathophysiology and Therapy May 11-13, 2011 in Atlanta, Georgia

2010

Peer reviewed articles - 2010

1 The biological role of nitrate and nitrite: the times they are a-changin',
Lundberg JO, Weitzberg E. Nitric Oxide. 2010 Feb 15;22(2):61-3. link

2 Nitrated oleic acid up-regulates PPARgamma and attenuates experimental inflammatory bowel disease,
Borniquel S, Jansson EA, Cole MP, Freeman BA, Lundberg JO. Free Radic Biol Med. 2010 Feb 15;48(4):499-505, link

3 Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise,
Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Radic Biol Med. 2010 Jan 15;48(2):342-7, link

4 Arginase inhibition mediates cardioprotection during ischaemia reperfusion,
Jung C, Gonon AT, Sjöquist PO, Lundberg JO, Pernow J. Cardiovasc Res. 2010 Jan 1;85(1):147-54, link

5 Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care,
Weitzberg E, Hezel M, Lundberg JO. Anesthesiology. 2010 Dec;113(6) 1460-75, link

7 Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice,
Carlström M, Larsen FJ, Nyström T, Hezel M, Borniquel S, Weitzberg E, Lundberg JO. Proc Natl Acad Sci U S A. 2010 Oct 12, link

8 NO-synthase independent NO generation in mammals,
Lundberg JO, Weitzberg E. Biochem Biophys Res Commun. 2010 May 21;396(1):39-45, link

9 Is sunlight good for our heart?
Feelisch M, Kolb-Bachofen V, Liu D, Lundberg JO, Revelo LP, Suschek CV,Weller RB. Eur Heart J. 2010 May;31(9):1041-5, link

10 Enhanced xanthine oxidoreductase expression and tissue nitrate reduction in germ free mice,
Huang L, Borniquel S, Lundberg JO. Nitric Oxide. 2010 Feb 15;22(2):191-5, link

11 Chocolate consumption, blood pressure, and cardiovascular risk,
Heiss C, Kelm M 1. Eur Heart J 2010 31:1554-1556, link

12 Flavanols and cardiovascular disease prevention,
Heiss C, Keen CL, Kelm M 2010, Eur Heart J. 31(21):2583-2592, link

13 Nitrate-nitrite-nitric oxide pathway, implications for anesthesiology and intensive care,
Weitzberg E, Hezel M, Lundberg JO. Anesthesiology. 2010
Dec;113(6):1460-75. Review. PubMed PMID: 21045638.


14 Enhanced xanthine oxidoreductase expression and tissue nitrate reduction in germ free mice,
Huang L, Borniquel S, Lundberg JO. Nitric Oxide. 2010 Feb 15;22(2):191-5. PubMed PMID: 20142047.
Presentations at conferences and workshops - 2010

NUTRIM symposium in Maastricht
Flaviola: Effects of Cocoa Flavanols on Cardiovascular Health, Erik J.B. Ruijters, Guido R.M.M. Haenen, Antje R. Weseler, Aalt Bast, Poster
FLAVIOLA Related publications - 2010

1 Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease,
Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile A, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y, 2010 J Am Coll Cardiol. 56:218-224, link

2 The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo,
Ottaviani JI, Momma TY, Heiss C, Kwik-Uribe C, Schroeter H, Keen CL 2011,Free Radic Biol Med 50:237-244, link

3 Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs,
Schroeter H, Heiss C, Spencer JPE, Keen CL, Lupton JR, Schmitz HH (2010) Mol Aspects Med. 31:546-557, link

2009

Peer reviewed articles - 2009

1 Nitrate and nitrite in biology, nutrition and therapeutics
Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, CabralesP, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M,Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurryK, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A,Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E, Nat Chem Biol. 2009 Dec; 5(12):865-9, link

2 The biological role of nitrate and nitrite: the times they are a-changin,
Lundberg JO, Weitzberg E. Nitric Oxide. 2010 Feb 15;22(2):61-3. Epub 2009 Nov 15. PubMed PMID: 19919855.
Presentations at conferences and workshops - 2009

3rd bi-annual Symposium on DNA methylation and cancer (Wim Vanden Berghe)
"Let food be your epigenetic medicine", symposium on Translational Cancer Epigenetics, October 09 2009, University Hospital of the RWTH Aachen

Düsseldorf, Germany, FLAVIOLA kick-off meeting
A public presentation of the project has been given during the first day of the kick-off meeting held in Düsseldorf, Germany (14/09/2009). It is a general introduction of the project available as a separate pdf file and can be downloaded from the public area of the FLAVIOLA web-site (link to the presentation)
Popular scientific articles, press releases, flyers - 2009

Press release
UDUS prepared a press release, which appeared on the homepage of UDUS on the 10th of September 2010 and in the Neue Ruhr Zeitung / Neue Rhein Zeitung (local newspaper) on September 13th 2010 (Link to the Journal)

FLAVIOLA Related publications - 2009

1 Abstract: Identification of a major mediator through which cocoa flavanols enhance vascular function. DGK 2009
Heiss C, Momma TY, Sievers RE, Chen Q, Keen CL, Yeghiazarians Y, Schroeter H, Springer ML (2009) Mannheim. Clin Res Cardiol 98- Suppl.

2 Abstract: Flavanol-rich Cocoa Mobilizes Endothelial Progenitor Cells Predicting the Reversal of Endothelial Dysfunction in Optimally Medicated CAD Patients,
Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile A, Rassaf T, Mihardja S, Devereaux M, Springer ML, Boyle A, Grossman W, Schroeter H, Yeghiazarians Y (2009)Clin Res Cardiol 98- Suppl 1,

3 Abstract: Flavanol-rich Cocoa Mobilizes Endothelial Progenitor Cells Predicting the Reversal of Endothelial Dysfunction in Optimally Medicated CAD Patients,
Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile A, Rassaf T, Mihardja S, Devereaux M, Springer ML, Boyle A, Grossman W, Schroeter H, Yeghiazarians Y (2009), Oral presentations

4 Stereochemical Properties of Flavanols Influence Vasodilatory Activity in vivo,
Momma TY, Ottaviani JI, Springer ML, Schroeter H, Keen CL, Heiss C (2009) ICPH 2009, Harrogate, UK.